Papers relevant to current projects (2019):


T cell colonies in memory

Featured on the cover
Singh, N. J., Bando, J.K. and Schwartz, R.H. (2012)
      Subsets of non-clonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells
Immunity, 37 (4): 735–746

    [ Full Text Article ]

Singh, N. J. (2016)
      Self-reactivity as the necessary cost of maintaining a diverse memory T cell repertoire.
Pathogens and Disease, 2016 Sep 11. pii: ftw092. [Epub ahead of print]

    [ Full Text Article ]

Tuning and tolerance in T cells

Singh, N. J. and Schwartz, R. H. (2003),
      The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells.
           Journal of Experimental Medicine 198: 1107-1117.

    [ Full Text Article ]

Featured on the cover
Singh, N. J., Chen, C. and Schwartz, R. H. (2006),
      The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance.
           PLoS Biology 4: e340.

   

Steinert, E., Schwartz, R.H., and Singh, N. J.(2012)
      At low precursor frequencies the helper T cell response to chronic self-antigen presentation in vivo, is followed by anergy without deletion.
           European Journal of Immunolology, 42:1-6

    [ Full Text Article ]

Innate-Adaptive communication

Abdi, K, Singh, N.J., Spooner, E, Kessler, B.M., Radaev, S., Lantz, L, Xiao, T.S., Matzinger,P., Sun, P.D., Ploegh, H.L.(2014)
      Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12-like Heterodimers Extracellularly.
            Journal of Immunology.;192(12):6028-36

    [ Full Text Article ]

Abdi, K &Singh, N.J., (2015)
      Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines.
            Cytokine.; 2015 Nov;76(1):53-7

    [ Full Text Article ]