Selected reading relevant to our projects
Papers relevant to current projects:
T cell colonies in memory
Subsets of non-clonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells
Immunity, 37 (4): 735–746 Singh, N. J. (2016)
Self-reactivity as the necessary cost of maintaining a diverse memory T cell repertoire.
Pathogens and Disease, 2016 Sep 11. pii: ftw092. [Epub ahead of print]
Tuning and tolerance in T cells
Singh, N. J. and Schwartz, R. H. (2003),
The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells.
Journal of Experimental Medicine 198: 1107-1117.
At low precursor frequencies the helper T cell response to chronic self-antigen presentation in vivo, is followed by anergy without deletion.
European Journal of Immunolology, 42:1-6
The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells.
Journal of Experimental Medicine 198: 1107-1117.
[ Full Text Article ]
The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance.
PLoS Biology 4: e340.
Steinert, E., Schwartz, R.H., and Singh, N. J.(2012)
At low precursor frequencies the helper T cell response to chronic self-antigen presentation in vivo, is followed by anergy without deletion.
European Journal of Immunolology, 42:1-6
Innate-Adaptive communication
Abdi, K, Singh, N.J., Spooner, E, Kessler, B.M., Radaev, S., Lantz, L, Xiao, T.S., Matzinger,P., Sun, P.D., Ploegh, H.L.(2014)
Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12-like Heterodimers Extracellularly.
Journal of Immunology.;192(12):6028-36 Abdi, K &Singh, N.J., (2015)
Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines.
Cytokine.; 2015 Nov;76(1):53-7
Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12-like Heterodimers Extracellularly.
Journal of Immunology.;192(12):6028-36 Abdi, K &Singh, N.J., (2015)
Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines.
Cytokine.; 2015 Nov;76(1):53-7